Appearance

White or almost white powder,fibrous aggregate

Solubility

Sparingly soluble or soluble in wafer, practically insoluble in acetone and in anhydrous ethanol.

Identification

A. Infrared absorption

Complies with the Ph.EUR.reference spectrum of sodium hyaluronate

B. Reaction of sodium

Appearance of solution

Positive

Clear

A600nm≤0.0 1

PH

5.0 〜8.5

Assay(on dry basis)

95.0% - 105.0%

Intrinsic viscosity

Actual value

Nucleic acids

A260nm≤0.5

Chlorides

≤0.5%

Iron

≤80ppm

Protein

≤0.1%

Loss on drying

≤20.0%

Microbiological purity:

-Total bacterial count

<100CFU/g

-Yeasts & mold

<20CFU/g

-Bacterial endotoxins

≤0.5IU/mg

-Staphylococcus aureus

Negative

-Pseudomonas aeruginosa

Negative

-Salmonella

Negative

-Escherichia coli

Negative

Residual solvents(Ethond)

≤5000ppm